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2-Nitrophenol → N-(4-Butylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}urea

HRID 1857166
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HRID 1857166 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N+]([O-])=O.[N+:25](C1C=CC=CC=1O)([O-])=O.[CH2:35]([C:39]1[CH:44]=[CH:43][C:42]([N:45]=[C:46]=[O:47])=[CH:41][CH:40]=1)[CH2:36][CH2:37][CH3:38]>C1(C)C=CC=CC=1>[CH2:35]([C:39]1[CH:44]=[CH:43][C:42]([NH:45][C:46]([NH:25][C:19]2[CH:20]=[CH:21][C:16]([O:15][C:6]3[C:5]4[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=4)[N:9]=[CH:8][CH:7]=3)=[CH:17][CH:18]=2)=[O:47])=[CH:41][CH:40]=1)[CH2:36][CH2:37][CH3:38]
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참가 물질

5

반응물 3

HCID 69472-NitrophenolHCID 27963134-Butylphenyl isocyanateHCID 221326976,7-Dimethoxy-4-(2-nitrophenoxy)quinoline

생성물 1

HCID 22132682N-(4-Butylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}urea수율 50%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

6,7-Dimethoxy-4-(2-aminophenoxy)quinoline (56 mg), which was obtained, analogously to Example 49, by reducing 6,7-dimethoxy-4-(2-nitrophenoxy)quinoline obtained in the same manner as described in Example 48, except that 2-nitrophenol was used in place of 4-nitrophenol, was dissolved in toluene (3 ml) with heat, 4-n-butylphenyl isocyanate (0.2 ml) was added, and the admixture was refluxed with heat for 30 minutes. The resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 45 mg of the title compound (yield: 50%).

후처리

  1. customobtained in the same manner
  2. temperaturewith heat
  3. temperaturethe admixture was refluxed
  4. temperaturewith heat for 30 minutes
  5. customThe resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1)

출처 및 근거

ORD 기록
ord-4d7ffb8cb31941cab6b331e987539a2e
출처 데이터셋
uspto-grants-2000_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06143764

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