N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(3-nitrophenyl)urea → N-(3-Aminophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

참여 물질

반응 단계

N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(3-nitrophenyl)urea (28 mg) was dissolved in N,N-dimethylformamide/ethyl acetate (5 ml/2.5 ml), 20% palladium hydroxide-carbon (97 mg) was added, and the admixture was stirred at room temperature under hydrogen for 3 hours. The reaction mixture was filtered using Celite, the filtrate was washed with brine and then dried with anhydrous sodium sulfate. The solvent was then removed by reduced-pressure distillation to obtain 13 mg of the title compound (yield: 51%).

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