Butyl isocyanate → HCID 22667145, 화합물

HRID 1857224노트

반응식

HRID 1857224 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.[CH2:23]([N:27]=[C:28]=[O:29])[CH2:24][CH2:25][CH3:26]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:28]([NH:27][CH2:23][CH2:24][CH2:25][CH3:26])=[O:29])=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 8110Butyl isocyanateHCID 116163634-(6,7-Dimethoxyquinazolin-4-yloxy)aniline

생성물 1

HCID 22667145HCID 22667145, 화합물수율 56%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

6,7-Dimethoxy-4-(4-aminophenoxy)quinazoline (100 mg) was dissolved in toluene (10 ml) with heat, n-butyl isocyanate (0.29 ml) was added, and the admixture was refluxed with heat for 40 minutes. After removing the solvent by distillation, the resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (5/1) to obtain 75 mg of the title compound (yield: 56%).

후처리

  1. temperaturewith heat
  2. temperaturethe admixture was refluxed
  3. temperaturewith heat for 40 minutes
  4. customAfter removing the solvent
  5. distillationby distillation
  6. customthe resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (5/1)

출처 및 근거

ORD 기록
ord-1fe79b7dff5246f9839e32ba7e24cc06
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143764

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