2-Chloro-4-nitrophenyl isocyanate → N-(2-Chloro-4-nitrophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

HRID 1857239노트

반응식

HRID 1857239 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.[Cl:23][C:24]1[CH:29]=[C:28]([N+:30]([O-:32])=[O:31])[CH:27]=[CH:26][C:25]=1[N:33]=[C:34]=[O:35]>C1(C)C=CC=CC=1>[Cl:23][C:24]1[CH:29]=[C:28]([N+:30]([O-:32])=[O:31])[CH:27]=[CH:26][C:25]=1[NH:33][C:34]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][C:6]2[C:5]3[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:9]=[CH:8][CH:7]=2)=[CH:21][CH:20]=1)=[O:35]

참가 물질

4

반응물 2

HCID 46142212-Chloro-4-nitrophenyl isocyanateHCID 115945434-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline

생성물 1

HCID 22132755N-(2-Chloro-4-nitrophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea수율 100%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (104 mg) was dissolved in toluene (10 ml) with heat, 2-chloro-4-nitrophenyl isocyanate (150 mg) was added, and the admixture was refluxed with heat for 10 minutes. The separated crystals were filtered and then washed with toluene to obtain 172 mg of the title compound (yield: 100%).

후처리

  1. temperaturewith heat
  2. temperaturethe admixture was refluxed
  3. temperaturewith heat for 10 minutes
  4. filtrationThe separated crystals were filtered
  5. washwashed with toluene

출처 및 근거

ORD 기록
ord-5a3db80752e64930aa9e3bf0a86418ad
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143764

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