Methyl 4-chloroanthranilate → 4-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-benzoic acid methyl ester

HRID 1857626

반응식

HRID 1857626 반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[NH2:11].[CH3:13][C:14]1[CH:15]=[C:16]([CH2:21][C:22](Cl)=[O:23])[CH:17]=[C:18]([CH3:20])[CH:19]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[NH:11][C:22](=[O:23])[CH2:21][C:16]1[CH:15]=[C:14]([CH3:13])[CH:19]=[C:18]([CH3:20])[CH:17]=1

참가 물질

3

반응물 2

HCID 80001Methyl 4-chloroanthranilateHCID 15895699(3,5-Dimethylphenyl)acetyl chloride

생성물 1

HCID 544849894-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-benzoic acid methyl ester수율 90.6%

실험 절차

To a solution of (3,5-dimethylphenyl)acetyl chloride (2.58 g in 20 mL dry dichloroethane) was added 2.5 g 2-amino-4-chlorobenzoic acid methyl ester and the mixture heated to reflux on an oil bath. After 2 hours, the pot was cooled to room temperature and the solvent removed in vacuo. Recrystallization of the crude product from methanol gave the title compound (4.05 g).

후처리

  1. temperaturethe mixture heated
  2. temperatureto reflux on an oil bath
  3. customthe solvent removed in vacuo
  4. customRecrystallization of the crude product from methanol

출처 및 근거

ORD 기록
ord-73d697ff42214d9db0de91482510aafd
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06147088

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