Methyl 2-amino-4-chloro-5-iodobenzoate → 4-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-iodo-benzoic acid methyl ester

HRID 1857630

반응식

HRID 1857630 반응식
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([I:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH2:12].[CH3:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23](Cl)=[O:24])[CH:18]=[C:19]([CH3:21])[CH:20]=1>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([I:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH:12][C:23](=[O:24])[CH2:22][C:17]1[CH:16]=[C:15]([CH3:14])[CH:20]=[C:19]([CH3:21])[CH:18]=1

참가 물질

3

반응물 2

HCID 10852539Methyl 2-amino-4-chloro-5-iodobenzoateHCID 15895699(3,5-Dimethylphenyl)acetyl chloride

생성물 1

HCID 540909164-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-iodo-benzoic acid methyl ester

반응 조건

온도
75 °C

실험 절차

To a solution of 2-amino-4-chloro-5-iodo-benzoic acid methyl ester (2.26 g in 25 mL dichloroethane) was added (3,5-dimethylphenyl) acetyl chloride (1.2 g in 15 mL dichloroethane) and the mixture heated to 75° C. on an oil bath. After 3 hours, the reaction was cooled and the solvent removed in vacuo. The title compound was isolated by crystallization from methanol (2.7 g).

후처리

  1. temperaturethe reaction was cooled
  2. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-135bf16af6e24199a6363aebf26854a5
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06147088

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