Potassium Hydroxide → 6-(1,4-Dioxa-8-azaspiro[4,5]dec-8-yl)-1,3,5-triazine-2,4-diamine

HRID 1857942노트

반응식

HRID 1857942 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4](Cl)[N:3]=1.[O:10]1[C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[O:13][CH2:12][CH2:11]1.[OH-].[K+]>O1CCOCC1.C(O)C.O>[O:10]1[C:14]2([CH2:19][CH2:18][N:17]([C:4]3[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([NH2:8])[N:5]=3)[CH2:16][CH2:15]2)[O:13][CH2:12][CH2:11]1

참가 물질

7

반응물 3

HCID 14797Potassium HydroxideHCID 188311,3,5-Triazine-2,4-diamine, 6-chloro-HCID 674351,4-Dioxa-8-azaspiro(4.5)decane

생성물 1

HCID 98164366-(1,4-Dioxa-8-azaspiro[4,5]dec-8-yl)-1,3,5-triazine-2,4-diamine

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

A mixture of 2,4-diamino-6-chloro-1,3,5-triazine (2 g, 14 mmol), 1,4-dioxa-8-azaspiro[4.5]decane (3 g, 21 mmol), and KOH (100 mg, 1.8 mmol) in dioxane (10 mL) and ethanol (40 mL) was heated at reflux overnight, diluted with water, and filtered. The precipitate was rinsed with water and dried under vacuum to provide the title compound.

후처리

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. filtrationfiltered
  4. washThe precipitate was rinsed with water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-698fd8cabfbe49b284e7f0777a4faaf4
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06150362

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