Piperidine → 4-(Piperidine-1-sulfonyl)benzonitrile
반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>C(Cl)Cl>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2]참가 물질
4
실험 절차
A mixture of 4-cyanobenzenesulfonyl chloride (0.51 g, 2.5 mmol) and piperidine (0.60 mL, 517 mg, 6.04 mmol) in 10 mL methylene chloride was stirred overnight at ambient temperature. The organic layer was washed successively with water, 5% HCl and brine, dried (Na2SO4) and concentrated. The resulting white solid (0.61 g, 96%) was used with no further purification.
후처리
- washThe organic layer was washed successively with water, 5% HCl and brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
- customThe resulting white solid (0.61 g, 96%) was used with no further purification
출처 및 근거
- ORD 기록
- ord-946cee777f0c4dcc932334c6dc9cabef
- 출처 데이터셋
- uspto-grants-2000_11
- 특허 번호
- US06150362
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