참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | {4-[2-(Diethylamino)ethoxy]phenyl}methanamine | HCID 235944 | — |
| 반응물 | 3-(2,6-dichlorophenyl)-7-methanesulfonyl-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | HCID 18425444 | — |
| 생성물 | HCID 22125117 | HCID 22125117 | 29.1% |
반응 단계
A mixture of 100 mg (0.26 mmol) of 3-(2,6-dichlorophenyl)-3,4-dihydro-7-methanesulfonyl-1-methylpyrimido[4,5-d]pyrimidin-2(1H)-one and 238 mg (1.07 mmol) of 4-(2-diethylaminoethoxy)benzylamine was heated at 170° C. for 30 minutes. The product was purified by flash column chromatography using dichloromethane/methanol/water/acetic acid (120:14:3:2) for the elution. Product-containing fractions were combined and evaporated to give 40 mg (29%) of 3-(2,6-dichlorophenyl)-7-[4-[2-(diethylamino)ethoxy]benzylamino]-3,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-2(1H)-one as a white solid of melting point 137-138° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06150373 |
|---|
| 출처 데이터셋 | uspto-grants-2000_11 |
|---|
| ORD ID | ord-c73134f7189d49b7af9d196d489e8769 |
|---|
| 출처 메모 | uspto-grants-2000_11 |
|---|
