Ethanol → tert-butyl (3RS,4RS)-4-[4-(3-hydroxy-propenyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

HRID 1858613노트

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HRID 1858613 반응식
[H-].C([Al+]CC(C)C)C(C)C.C([O:13][C:14]([CH:16]=[CH:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]2[CH2:29][CH2:28][N:27]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:26][CH:25]2[O:37][CH2:38][C:39]2[CH:48]=[CH:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[CH:40]=2)=[CH:20][CH:19]=1)=O)C.C(O)C.C(C(C(C([O-])=O)O)O)([O-])=O.[Na+].[K+]>C1(C)C=CC=CC=1.O>[OH:13][CH2:14][CH:16]=[CH:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]2[CH2:29][CH2:28][N:27]([C:30]([O:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:31])[CH2:26][CH:25]2[O:37][CH2:38][C:39]2[CH:48]=[CH:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[CH:40]=2)=[CH:20][CH:19]=1

참가 물질

7

반응물 4

HCID 702EthanolHCID 9855836Potassium sodium tartarateHCID 21225700DiisobutylaluminumhydrideHCID 53757216tert-butyl (3RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

생성물 1

HCID 53719730tert-butyl (3RS,4RS)-4-[4-(3-hydroxy-propenyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate수율 55.4%

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

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온도
-50 °C

실험 절차

5 ml (5 mmol) of a solution of diisobutylaluminium hydride (DIBAH) (1M in hexane) were added dropwise at -50° C. to a solution of 698 mg (1.35 mmol) of tert-butyl (3RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate in 15 ml of toluene and the mixture was stirred at -50° C. for 30 minutes. Subsequently, the reaction mixture was treated dropwise at -50° C. with 10 ml of ethanol and warmed to room temperature. For the working-up, the reaction mixture was treated with 20 ml of water and 20 ml of saturated potassium sodium tartrate solution while cooling with ice and thereafter extracted three times with 50 ml of ethyl acetate each time. The organic phases were combined, dried over sodium sulphate and evaporated under reduced pressure. The crude product was chromatographed on silica gel using a 6:4 mixture of hexane and ethyl acetate as the eluent. There were obtained 354 mg (55% of theory) of tert-butyl (3RS,4RS)-4-[4-(3-hydroxy-propenyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate as a colourless solid; MS: 474 (M+H)+.

후처리

  1. temperaturewarmed to room temperature
  2. temperaturewhile cooling with ice
  3. extractionextracted three times with 50 ml of ethyl acetate each time
  4. dry with materialdried over sodium sulphate
  5. customevaporated under reduced pressure
  6. customThe crude product was chromatographed on silica gel using
  7. additiona 6:4 mixture of hexane and ethyl acetate as the eluent

출처 및 근거

ORD 기록
ord-d83ee34ce47d41ddaa1a4351553d59b1
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06150526

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