Potassium Carbonate → HCID 53656586, 화합물

HRID 1858775노트

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HRID 1858775 반응식
OC1C(C2C=CC(O)=CC=2)CCN(C(OC(C)(C)C)=O)C1.BrCCCC1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+].[OH:38][CH:39]1[CH:44]([C:45]2[CH:50]=[CH:49][C:48]([O:51][CH2:52][CH2:53][CH2:54][C:55]3[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=3)=[CH:47][CH:46]=2)[CH2:43][CH2:42][N:41]([C:61]([O:63][C:64]([CH3:67])([CH3:66])[CH3:65])=[O:62])[CH2:40]1.Br[CH2:69][C:70]1[CH:79]=[CH:78][C:77]2[C:72](=[CH:73][CH:74]=[CH:75][CH:76]=2)[CH:71]=1>>[CH:71]1[C:72]2[C:77](=[CH:76][CH:75]=[CH:74][CH:73]=2)[CH:78]=[CH:79][C:70]=1[CH2:69][O:38][CH:39]1[CH:44]([C:45]2[CH:46]=[CH:47][C:48]([O:51][CH2:52][CH2:53][CH2:54][C:55]3[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=3)=[CH:49][CH:50]=2)[CH2:43][CH2:42][N:41]([C:61]([O:63][C:64]([CH3:67])([CH3:66])[CH3:65])=[O:62])[CH2:40]1

참가 물질

6

반응물 5

HCID 11430Potassium CarbonateHCID 12503(3-Bromopropyl)benzeneHCID 703202-BromomethylnaphthaleneHCID 21713087(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylateHCID 86604476tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(3-phenyl-propoxy)-phenyl]-piperidine-1-carboxylate

생성물 1

HCID 53656586HCID 53656586, 화합물

실험 절차

In an analogous manner to that described in Example 44(e), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-(4-hydroxy-phenyl)-piperidine-1-carboxylate [Example 46(b)] with 1-bromo-3-phenyl-propane in the presence of potassium carbonate, tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(3-phenyl-propoxy)-phenyl]-piperidine-1-carboxylate, alkylation of which analogously to Example 1(g) with 2-bromomethyl-naphthalene yielded tert-butyl (3RS,4RS)-3-(naphthalen-2-ylmethoxy)-4-[4-(3-phenyl-propoxy)-phenyl]-piperidine-1-carboxylate as a colourless solid; MS: 551 (M)+.

출처 및 근거

ORD 기록
ord-fb76617638ae4b6e9d7b03787224d46e
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06150526

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