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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1858787생성일: 2026년 10월 26일

2-Chloromethyl-1,4-dimethoxy-naphthalene → tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate

https://huagongshe.com/reaction/1858787

반응식

참여 물질

역할이름HCID투입량
반응물2-Chloromethyl-1,4-dimethoxy-naphthaleneHCID 14854802—
반응물tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylateHCID 86604483—
생성물tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylateHCID 86604484—

반응 단계

In an analogous manner to that described in Example 1(g), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate with 2-chloromethyl-1,4-dimethoxy-naphthalene there was obtained tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-[4-(2-phenethyloxy-ethoxy)-phenyl]-piperidine-1-carboxylate as a yellow solid; MS: 642 (M+H)+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06150526
출처 데이터셋uspto-grants-2000_11
ORD IDord-f5262d02d83446a1bc8cffe33535c74b
출처 메모uspto-grants-2000_11