4-Methylisoquinoline-5-sulfonyl chloride → HCID 70275386, 화합물

HRID 1858918노트

반응식

HRID 1858918 반응식
C(OC([N:8]1[CH2:13][C@H:12]([CH3:14])[NH:11][CH2:10][C@@H:9]1[CH3:15])=O)(C)(C)C.[Cl:16][S:17]([C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[C:22]([CH3:30])=[CH:23][N:24]=[CH:25]2)(=[O:19])=[O:18]>>[ClH:16].[ClH:16].[CH3:15][C@H:9]1[CH2:10][NH:11][C@@H:12]([CH3:14])[CH2:13][N:8]1[S:17]([C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[C:22]([CH3:30])=[CH:23][N:24]=[CH:25]2)(=[O:18])=[O:19]

참가 물질

3

반응물 2

HCID 154871104-Methylisoquinoline-5-sulfonyl chlorideHCID 24903577tert-Butyl (2S,5S)-2,5-dimethylpiperazine-1-carboxylate

생성물 1

HCID 70275386HCID 70275386, 화합물수율 51.3%

실험 절차

Using 0.43 g of cis-1-(tert-butoxycarbonyl)-2,5-dimethylpiperazine and 0.48 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.2 g of the objective compound (white crystals).

출처 및 근거

ORD 기록
ord-9de509a29d4f4a9bb5a050d09dabb6d3
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06153608

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