Cyanogen Bromide → 2-Chloro-5-ethylphenylcyanamide

HRID 1858986노트

반응식

HRID 1858986 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([CH2:9][CH3:10])=[CH:5][C:3]=1[NH2:4].Br[C:12]#[N:13]>O>[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([CH2:9][CH3:10])=[CH:5][C:3]=1[NH:4][C:12]#[N:13]

참가 물질

4

반응물 2

HCID 10476Cyanogen BromideHCID 124650462-Chloro-5-ethylaniline

생성물 1

HCID 105593012-Chloro-5-ethylphenylcyanamide수율 100.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a heterogeneous slurry of 2-chloro-5-ethylaniline (1.6 g, 10 mmol) in 60 mL of water at 4° C. was added solid BrCN (0.848 g, 8 mmol) slowly. After 5 minutes the cooling bath was removed and the heterogeneous reaction mixture was stirred at room temperature for 24 hours to yield the product in water suspension. The precipitates were collected by filtration, washed with water (100 mL), and dried under vacuum to yield the pure title compound (1.45 g, 80% yield).

후처리

  1. customAfter 5 minutes the cooling bath was removed
  2. customto yield the product in water suspension
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water (100 mL)
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-63774565f3e0431f925976ea2cb9b52a
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06153604

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