Benzaldehyde → 2-Benzylidene-1,3-indandione

HRID 1859077

반응식

HRID 1859077 반응식
[C:1]1(=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])[CH2:2]1.[CH:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1C=CC=CC=1.N1CCCCC1>[CH:12](=[C:2]1[C:1](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:10])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 2

HCID 240BenzaldehydeHCID 118151,3-Indandione

생성물 1

HCID 2378222-Benzylidene-1,3-indandione수율 72.1%

시약·촉매·용매 2

HCID 8082Piperidine촉매HCID 241Benzene용매

실험 절차

To a solution of 1,3-indandione (43.8 g) and piperidine (44 mg) in dry benzene (500 ml) was added benzaldhyde (31.8 g). The mixture was heated to reflux and the water generated was removed by Dean-Stark trap. After 24 hours, the mixture was evaporated to dryness. The residue was recrystallized from ethanol (200 ml) to give 2-benzylidene-1,3-indandione as a yellow solid (50.6 g).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. customthe water generated was removed by Dean-Stark trap
  4. customthe mixture was evaporated to dryness
  5. customThe residue was recrystallized from ethanol (200 ml)

출처 및 근거

ORD 기록
ord-4cdc2d56b9d643e9bb22b4106b8ec394
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06153645

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