참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Chloride | HCID 4873 | — |
| 반응물 | 2-Hydroxybenzonitrile | HCID 11907 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Potassium | HCID 5462222 | — |
| 반응물 | Methyl (2E)-2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyprop-2-enoate | HCID 11782200 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Azoxystrobin | HCID 3034285 | 77.7% |
반응 단계
A slurry of the potassium salt of 2-cyanophenol containing potassium chloride was prepared by mixing 2-cyanophenol (13.2 g), potassium hydroxide (6.8 g) and potassium chloride (20 g) in water (10 g). This solution was added to (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxypropenoate (32.8 g) over 5 minutes while maintaining the temperature at 95-100° C. The resulting mixture was stirred at 110° C. for 3 hours. The reaction mixture was mixed with water and toluene and the organic layer separated. The toluene solution contained (E)-methyl 2-[2-(6- (2-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate (77.7% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06153750 |
|---|
| 출처 데이터셋 | uspto-grants-2000_11 |
|---|
| ORD ID | ord-a3ce5071321f45feb5179ea7c1d033ec |
|---|
| 출처 메모 | uspto-grants-2000_11 |
|---|
