Ethanol → 1-(4,4,5,5,5-Pentafluoropentyl)piperazine

HRID 1859347노트

반응식

HRID 1859347 반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(O)C.[F:10][C:11]([F:31])([C:27]([F:30])([F:29])[F:28])[CH2:12][CH2:13][CH2:14]OC1C=CC=C(C)C=1S([O-])(=O)=O>O>[F:10][C:11]([F:31])([C:27]([F:30])([F:29])[F:28])[CH2:12][CH2:13][CH2:14][N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 702EthanolHCID 4837PiperazineHCID 867560744,4,5,5,5-Pentafluoropentyloxytoluenesulfonate

생성물 1

HCID 221236141-(4,4,5,5,5-Pentafluoropentyl)piperazine수율 100%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Piperazine (777 mg, 9.0 mmol) was added to ethanol solution (10 ml) of 4,4,5,5,5-pentafluoropentyloxytoluenesulfonate (600 mg, 1.81 mmol) and then heated under refluxing for 40 hours. After adding water, the reaction solution was extracted with ethyl acetate. The solvent was distilled off under reduced pressure from the extract to obtain 315 mg (yield: 100%) of the title compound.

후처리

  1. temperatureheated
  2. temperatureunder refluxing for 40 hours
  3. extractionthe reaction solution was extracted with ethyl acetate
  4. distillationThe solvent was distilled off under reduced pressure from the
  5. extractionextract

출처 및 근거

ORD 기록
ord-f963d98051544e3db366144d0bfe444d
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06153768

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