홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylamine → 3-Hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic Acid Tert-Butyl Ester

HRID 1859524
노트
인쇄 미리보기

반응식

HRID 1859524 반응식
[C:1]([O:4][C:5]([CH3:8])([CH3:7])[CH3:6])(=[O:3])[CH3:2].C(NC(C)C)(C)C.[Li]CCCC.[CH3:21][CH:22]([CH3:32])[C:23](=[O:31])[CH2:24][CH2:25][C:26]1[CH:30]=[CH:29][S:28][CH:27]=1>C1COCC1>[C:5]([O:4][C:1](=[O:3])[CH2:2][C:23]([OH:31])([CH2:24][CH2:25][C:26]1[CH:30]=[CH:29][S:28][CH:27]=1)[CH:22]([CH3:21])[CH3:32])([CH3:8])([CH3:7])[CH3:6]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 7912DiisopropylamineHCID 10908tert-Butyl acetateHCID 124772794-Methyl-1-thiophen-3-yl-pentan-3-oneHCID 178418339Butyllithium

생성물 1

HCID 572276173-Hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic Acid Tert-Butyl Ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran
용매

실험 절차

The title compound was prepared as described in General Method 9 using t-butyl acetate (42.6 mmol), diisopropyl amine (42.6 mmol), nBuLi (42.6 mmol), 4-methyl-1-thiophen-3-yl-pentan-3-one (Example C-5; 21.3 mmol), and THF (100 mL). The title compound was purified by flash chromatography over silica gel eluting with hexane:EtOAc 97:3. 1NMR (CDCl3): δ0.95 (dd, 6 H), 1.47 (s, 9 H), 1.7-2.0 (m, 3 H), 2.36-2.54 (AB q, 2 H), 2.6-2.8 (m, 2 H), 6.93-6.95 (m, 2 H), 7.23-7.25 (m, 1 H).

후처리

  1. customThe title compound was purified by flash chromatography over silica gel eluting with hexane:EtOAc 97:3

출처 및 근거

ORD 기록
ord-98e0d8ca2ab7431fadb95acb943fcc43
출처 데이터셋
uspto-grants-2003_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06528510B1

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트