Potassium Cyanide → 3-(3-Methoxy-4-methylphenyl)propyl cyanide

HRID 1859809노트

반응식

HRID 1859809 반응식
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([O:12][CH3:13])[CH:6]=1.[C-:14]#[N:15].[K+]>CC(C)=O.CCO.O>[CH3:13][O:12][C:7]1[CH:6]=[C:5]([CH2:4][CH2:3][CH2:2][C:14]#[N:15])[CH:10]=[CH:9][C:8]=1[CH3:11]

참가 물질

6

반응물 2

HCID 9032Potassium CyanideHCID 186265044-(3-Bromopropyl)-2-methoxy-1-methylbenzene

생성물 1

HCID 186265273-(3-Methoxy-4-methylphenyl)propyl cyanide수율 100%

시약·촉매·용매 3

HCID 180Acetone용매HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 8.68 g (35.7 mmol) of 4-(3-bromopropyl)-2-methoxy-1-methylbenzene in 50 mL of acetone and 50 mL of EtOH was treated with a solution of 2.8 g (42.8 mmol) of KCN in 20 mL of H2O and heated at reflux overnight. The solvent was removed under reduced pressure and the residue taken up in EtOAc and washed with H2O, then saturated NaCl. Drying over MgSO4 and removal of the solvent under reduced pressure left 6.75 g (100% yield) of the product as an oil. The structure was confirmed by NMR and IR spectroscopy.

후처리

  1. temperatureheated
  2. temperatureat reflux overnight
  3. customThe solvent was removed under reduced pressure
  4. washwashed with H2O
  5. dry with materialDrying over MgSO4 and removal of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-e599833520eb40b18de2ec28474f1937
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528535B2

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