Methanesulfonyl chloride → Ethyl 3-[4-(2-methanesulfonyloxyethoxy)phenyl]-2-phenoxypropionate

HRID 1859959노트

반응식

HRID 1859959 반응식
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>C(N(CC)CC)C>[CH3:25][S:26]([O:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH:12]([O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:9][CH:10]=1)(=[O:28])=[O:27]

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 18625939Ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-phenoxypropionate

생성물 1

HCID 18625787Ethyl 3-[4-(2-methanesulfonyloxyethoxy)phenyl]-2-phenoxypropionate

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 3-[4-(2-hydroxyethoxy)phenyl]-2-phenoxypropionate (3.27 g), which is the product of Reference example 4(e), triethylamine (2.07 ml) and methanesulfonyl chloride (0.84 ml) and the reaction mixture was treated to afford the desired compound (4.20 g) as a syrup.

후처리

  1. additionthe reaction mixture was treated

출처 및 근거

ORD 기록
ord-84c6fb28bba44922b1c081fb738b5545
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528525B1

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