1,1'-Carbonyldiimidazole → Ethyl 2-butyl-3-[4-[2-(4'-methoxycarbonylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate

반응식

[NH2:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH2:18][CH2:19][CH2:20][CH3:21])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:7][CH:6]=1.[CH3:22][O:23][C:24]([C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:37]=[CH:36][C:35]([C:38](O)=[O:39])=[CH:34][CH:33]=2)=[CH:28][CH:27]=1)=[O:25].C(N1C=CN=C1)(N1C=CN=C1)=O>>[CH2:18]([CH:12]([CH2:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][NH:1][C:38]([C:35]2[CH:36]=[CH:37][C:32]([C:29]3[CH:30]=[CH:31][C:26]([C:24]([O:23][CH3:22])=[O:25])=[CH:27][CH:28]=3)=[CH:33][CH:34]=2)=[O:39])=[CH:6][CH:7]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:19][CH2:20][CH3:21]

참가 물질

반응물 3

HCID 682631,1'-Carbonyldiimidazole

HCID 142508264-[4-(Methoxycarbonyl)phenyl]benzoic acid

HCID 18625891Ethyl 3-[4-(2-aminoethoxy)phenyl]-2-butylpropionate

생성물 1

HCID 18626044Ethyl 2-butyl-3-[4-[2-(4'-methoxycarbonylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate수율 37.8%

실험 절차

In a similar manner to that described in Example 5, a reaction was carried out using ethyl 3-[4-(2-aminoethoxy)phenyl]-2-butylpropionate (375 mg), which is the product of Reference example 6, 4′-methoxycarbonylbiphenyl-4-carboxylic acid (328 mg) and carbonyldiimidazole (225 mg) and the reaction mixture was treated to afford the title compound (257 mg) as colorless crystals.