Ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate → Ethyl 3-(4-hydroxyphenyl)-2-(4-methylphenoxy)propionate

HRID 1860060노트

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HRID 1860060 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:22][C:23]2[CH:24]=[CH:25][C:26]([CH3:29])=[CH:27][CH:28]=2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1

참가 물질

3

반응물 1

HCID 18625971Ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate

생성물 1

HCID 18626029Ethyl 3-(4-hydroxyphenyl)-2-(4-methylphenoxy)propionate수율 103.9%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

In a similar manner to that described in Reference example 1(d), a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)-2-(4-methylphenoxy)propionate (2.84 g), which is the product of Reference example 35(b), and palladium on carbon (284 mg) and the reaction mixture was treated to afford the desired compound (2.27 g) as a syrup.

후처리

  1. additionthe reaction mixture was treated

출처 및 근거

ORD 기록
ord-4a4b0b236bc4468495f668469663b16c
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528525B1

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