Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate → Ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

HRID 1860075노트

반응식

HRID 1860075 반응식
C(O[C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([OH:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:14][CH:13]=1)=[O:7])(C)(C)C.Cl.[N:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:33]1[CH:41]=[CH:40][C:36](C(Cl)=O)=[CH:35][CH:34]=1>C(N(CC)CC)C>[OH:25][CH:19]([CH2:18][C:15]1[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:36]2[CH:35]=[CH:34][C:33]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][N:27]=3)=[CH:41][CH:40]=2)=[CH:17][CH:16]=1)[C:20]([O:22][CH2:23][CH3:24])=[O:21]

참가 물질

4

반응물 2

HCID 18625730Ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionateHCID 186259104-(2-Pyridinyl)benzoyl Chloride Hydrochloride

생성물 1

HCID 18625968Ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate수율 91%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

In a similar manner to that described in Example 126, a reaction was carried out using ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate (168 mg), 4-pyridine-2-ylbenzoylchloride hydrochloride (126 mg) and triethylamine (0.28 ml) and the reaction mixture was treated to afford the title compound (188 mg) as colorless crystals.

후처리

  1. additionthe reaction mixture was treated

출처 및 근거

ORD 기록
ord-ddbc3c231a354e7d9245f9d85f3efe5f
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528525B1

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