Ethyl 3-(4-benzyloxyphenyl)-2-aminopropionate → Ethyl 3-(4-benzyloxyphenyl)-2-(pyrrole-1-yl)propionate

HRID 1860103노트

반응식

HRID 1860103 반응식
Cl[CH:2](OC)[CH2:3][CH2:4][CH:5](Cl)OC.[CH2:11]([O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH:26]([NH2:32])[C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:21][CH:20]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>ClCCl>[CH2:11]([O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH:26]([N:32]2[CH:5]=[CH:4][CH:3]=[CH:2]2)[C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:21][CH:20]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 4681968Ethyl 3-(4-benzyloxyphenyl)-2-aminopropionateHCID 128533161,4-Dichloro-1,4-dimethoxybutane

생성물 1

HCID 18625911Ethyl 3-(4-benzyloxyphenyl)-2-(pyrrole-1-yl)propionate수율 26%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1,4-dichloro-1,4-dimethoxybutane (3.30 g) was added to a solution of ethyl 3-(4-benzyloxyphenyl)-2-aminopropionate (3.30 g) in dichloromethane (80 ml) and then amberlyst A-21 (20 g) was added to the mixture. The mixture was stirred at ambient temperature for 18 hours and the reaction mixture was filtered. The filtrate was concentrated and the residue was purified via chromatography on a silica gel column using ethyl acetate/hexane=1/5 as the eluant to afford the desired compound (1.00 g) as a syrup.

후처리

  1. additionamberlyst A-21 (20 g) was added to the mixture
  2. filtrationthe reaction mixture was filtered
  3. concentrationThe filtrate was concentrated
  4. customthe residue was purified via chromatography on a silica gel column

출처 및 근거

ORD 기록
ord-a84d82773088476f828f7fcd75eee02b
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528525B1

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