Ethyl 3-(4-benzyloxyphenyl)-2-(pyrrole-1-yl)propionate → Ethyl 3-(4-hydroxyphenyl)-2-(pyrrole-1-yl)propionate

HRID 1860104노트

반응식

HRID 1860104 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([N:22]2[CH:26]=[CH:25][CH:24]=[CH:23]2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([N:22]2[CH:26]=[CH:25][CH:24]=[CH:23]2)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:14]=1

참가 물질

3

반응물 1

HCID 18625911Ethyl 3-(4-benzyloxyphenyl)-2-(pyrrole-1-yl)propionate

생성물 1

HCID 18625802Ethyl 3-(4-hydroxyphenyl)-2-(pyrrole-1-yl)propionate수율 95.7%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

In a similar manner to that described in Reference example 55(b), a reaction was carried out using ethyl 3-(4-benzyloxyphenyl)-2-(pyrrole-1-yl)propionate (1.00 g) obtained in Reference example 57(a) and palladium on carbon (5%, 0.12 g) and the reaction mixture was treated to afford the title compound (0.71 g) as a syrup.

후처리

  1. additionthe reaction mixture was treated

출처 및 근거

ORD 기록
ord-a3899f6d83da49a5befaedf0a21ee70a
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528525B1

반응 노트

불러오는 중…