[O:1]=[C:2]1[NH:6][C:5]2[S:7][C:8]([C:10]#[N:11])=[CH:9][C:4]=2[CH2:3]1.[NH:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[CH:17]=O>N1CCCCC1.CC(O)C>[O:1]=[C:2]1[NH:6][C:5]2[S:7][C:8]([C:10]#[N:11])=[CH:9][C:4]=2/[C:3]/1=[CH:17]/[C:13]1[NH:12][CH:16]=[CH:15][CH:14]=15,6-Dihydro-5-oxo-4H-thieno[2,3-b]pyrrole-2-carbonitrile (32 mg, 0.2 mmol) was dissolved in a solution of 1% piperidine in 2-propanol (1 ml). Pyrrole-2-carboxaldehyde (37 mg, 0.39 mmol) was added in one portion and the mixture heated at 75° C. for 1 hour. The reaction mixture was poured into an ice/water mixture (6 ml) and the precipitated solid was collected by filtration and washed with water to give 10 mg of (Z)-5,6-dihydro-5-oxo-4-[(1H-pyrrol-2-yl)methylene]-4H-thieno[2,3-b]pyrrole-2-carbonitrile as a yellow solid. MS(ES): m/e 242 [M+H].
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