Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 5-Nitro-2-thiophenecarboxaldehyde oxime
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 5-Nitrothiophene-2-carboxaldehyde | HCID 78281 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Water ethanol | HCID 19096565 | — |
| 생성물 | 5-Nitro-2-thiophenecarboxaldehyde oxime | HCID 350516 | 79.9% |
반응 단계
A mixture of 5-nitrothiophene-2-carboxaldehyde (10 g, 64 mmol), hydroxylamine hydrochloride (9.4 g, 130 mmol) and sodium hydroxide (4.34 g, 107 mmol) in ethanol/water (150 ml, 2:1) was heated to reflux for 2 hours, then diluted with dichloromethane and washed with water. The organic layer was dried over magnesium sulfate and evaporated to dryness to give 8.8 g of 5-nitro-2-thiophene-carboxaldehyde oxime as a tan solid. 1H NMR (400 MHz, DMSO-d6) δ: 7.54 (1H, d), 8.13 (1H, s), 8.16 (1H, d), 13.14 (1H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06528653B2 |
| 출처 데이터셋 | uspto-grants-2003_03 |
| ORD ID | ord-1b980d0a384e46658c2dd869af003b5c |
| 출처 메모 | uspto-grants-2003_03 |