Potassium Hydroxide → Flumethasone

반응식

[CH3:1][C@H:2]1[C@:19]([OH:27])([C:20]([CH2:22][O:23]C(C)=O)=[O:21])[C@:18]2([CH3:28])[C@H:4]([C@H:5]3[C@:15]([F:30])([C@@H:16]([OH:29])[CH2:17]2)[C@:14]2([CH3:31])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[C@@H:7]([F:32])[CH2:6]3)[CH2:3]1.[OH-].[K+]>>[CH3:1][C@H:2]1[C@:19]([OH:27])([C:20]([CH2:22][OH:23])=[O:21])[C@:18]2([CH3:28])[C@H:4]([C@H:5]3[C@:15]([F:30])([C@@H:16]([OH:29])[CH2:17]2)[C@:14]2([CH3:31])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[C@@H:7]([F:32])[CH2:6]3)[CH2:3]1

참가 물질

반응물 2

HCID 14797Potassium Hydroxide

HCID 11155198Flumethasone Acetate

생성물 1

HCID 16490Flumethasone

실험 절차

A process according to claim 1, characterized by the fact that the flumethasone 21-acetate is reacted with methanolic potassium hydroxide in the absence of an oxidization agent to yield flumethasone.

출처 및 근거

ORD 기록: ord-f41311e2dbb145aca0f11adab5579f21
출처 데이터셋: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06528666B1

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