5-(Piperazin-1-yl)benzofuran-2-carboxamide → Vilazodone

HRID 1860621

반응식

HRID 1860621 반응식
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([C:15]([NH2:17])=[O:16])=[CH:12][C:11]=3[CH:18]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[CH2:20][CH2:21][CH2:22][CH2:23][C:24]1[C:32]2[C:27](=[CH:28][CH:29]=[C:30]([C:33]#[N:34])[CH:31]=2)[NH:26][CH:25]=1>>[C:33]([C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:23][CH2:22][CH2:21][CH2:20][N:4]1[CH2:3][CH2:2][N:1]([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([C:15](=[O:16])[NH2:17])=[CH:12][C:11]=3[CH:18]=2)[CH2:6][CH2:5]1)#[N:34]

참가 물질

3

반응물 2

HCID 98347195-(Piperazin-1-yl)benzofuran-2-carboxamideHCID 98811233-(4-Chlorobutyl)-5-cyanoindole

생성물 1

HCID 6918314Vilazodone

실험 절차

in that 5-(1-piperazinyl)benzofuran-2-carboxamide is reacted with 3-(4-chlorobutyl)-5-cyanoindole to give 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine and

출처 및 근거

ORD 기록
ord-e93e5314ea4d4fc3b7855f967dff88b7
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06531503B1

연결된 노트

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