Methyl 2,2,2-trichloroacetimidate → 5-Fluoro-2-trichloromethyl-1H-benzoimidazole-4-carboxylic acid ethyl ester

반응식

[CH2:1]([O:3][C:4](=[O:14])[C:5]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]([NH2:12])[C:6]=1[NH2:13])[CH3:2].CO[C:17](=N)[C:18]([Cl:21])([Cl:20])[Cl:19]>>[CH2:1]([O:3][C:4]([C:5]1[C:6]2[N:13]=[C:17]([C:18]([Cl:21])([Cl:20])[Cl:19])[NH:12][C:7]=2[CH:8]=[CH:9][C:10]=1[F:11])=[O:14])[CH3:2]

참가 물질

반응물 2

HCID 100479Methyl 2,2,2-trichloroacetimidate

HCID 58101800Ethyl 2,3-diamino-6-fluorobenzoate

생성물 1

HCID 686173265-Fluoro-2-trichloromethyl-1H-benzoimidazole-4-carboxylic acid ethyl ester

실험 절차

5-Fluoro-2-trichloromethyl-1H-benzoimidazole-4-carboxylic acid ethyl ester was prepared by a procedure according to example 5 (i) starting from 150.0 mg (0.76 mmol) 2,3-Diamino-6-fluoro-benzoic acid ethyl ester and 133 μl (1.06 mmol) 2,2,2-trichloro-acetimidic acid methyl ester.

출처 및 근거

ORD 기록: ord-645f30d875364c4f8877808e6fce07c8
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07741341B2

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