8-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid → 8-Bromo-4,4-dimethyl-6-chromanoic Acid

반응식

[Br:1][C:2]1[CH:3]=[C:4]([C:16]([OH:18])=[O:17])[CH:5]=[C:6]2[C:11]=1[O:10][C:9](C)(C)[CH2:8][C:7]2([CH3:15])[CH3:14].CC1(C)C2C(=CC=CC=2)OC(C(O)=O)C1>>[Br:1][C:2]1[CH:3]=[C:4]([C:16]([OH:18])=[O:17])[CH:5]=[C:6]2[C:11]=1[O:10][CH2:9][CH2:8][C:7]2([CH3:14])[CH3:15]

참가 물질

반응물 2

HCID 158405358-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid2회

HCID 230017694,4-Dimethylchromanoic acid

생성물 1

HCID 158405348-Bromo-4,4-dimethyl-6-chromanoic Acid

실험 절차

Using the same procedure as for the synthesis of 8-bromo-2,2,4,4-tetramethylchromanoic acid (Compound P) but using 4,4-dimethylchromanoic acid (100 mg, 0.49 mmol), the title compound was obtained as a white solid.

출처 및 근거

ORD 기록: ord-5c39fde2b592431b86ecd6722c164006
출처 데이터셋: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06534544B1

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