Lithium diisopropylamide → 2-(2-Benzyloxyphenyl)-2-methylpropionic acid methyl ester

HRID 1861966노트

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HRID 1861966 반응식
[CH3:1]OC(=O)CC1C=CC=CC=1OCC1C=CC=CC=1.CC(C)([O-])C.[K+].[CH3:26][O:27][C:28](=[O:45])[CH:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[CH3:30].C([N-]C(C)C)(C)C.[Li+]>>[CH3:26][O:27][C:28](=[O:45])[C:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH2:38][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1)([CH3:1])[CH3:30]

참가 물질

5

반응물 4

HCID 2724682Lithium diisopropylamideHCID 11076055Methyl 2-(2-(benzyloxy)phenyl)acetateHCID 23665647Potassium tert-butoxideHCID 54327103HCID 54327103, 화합물2회

생성물 1

HCID 229809602-(2-Benzyloxyphenyl)-2-methylpropionic acid methyl ester수율 70%

실험 절차

Using 2-benzyloxyphenylacetic acid methyl ester as a starting material and also using potassium t-butoxide as a base, the same procedure of Example la gave 2-(2-benzyloxyphenyl)propioic acid methyl ester. Using lithium diisopropylamide as a base, the resulting 2-(2-benzyloxyphenyl)propionic acid methyl ester was further treated as in Example la to give 4.72 g of the titled compound (yield, 70%).

출처 및 근거

ORD 기록
ord-99449d72cc5f4ef3980fe2a72b31d7eb
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06534546B1

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