Ethanolamine → Methanesulfonic acid 8-(2-hydroxyacetylamino)naphthalen-2-yl ester
반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[CH:14]=[C:13]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH:12]=[CH:11]2)=[O:4].C(CN)[OH:22]>C(OC(C)=O)(C)C>[OH:22][CH2:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[CH:14]=[C:13]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH:12]=[CH:11]2)=[O:4]참가 물질
4
실험 절차
To a solution of ester from Step B (11.0 g, 39.5 mmol) in 150 mL of i-PrOAc at room temperature was added ethanolamine (12.0 mL, 199 mmol). After 18 hours, the reaction was partitioned between EtOAc and water, and the organic layer was extracted with saturated brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide a dark oil.
후처리
- customthe reaction was partitioned between EtOAc and water
- extractionthe organic layer was extracted with saturated brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
- customto provide a dark oil
출처 및 근거
- ORD 기록
- ord-fb6d84caeb864c26a6a86166673ff955
- 출처 데이터셋
- uspto-grants-2003_03
- 특허 번호
- US06534506B2
반응 노트
불러오는 중…