Pamidronic Acid → Pamidronate Disodium Anhydrous

참여 물질

반응 조건

반응 단계

Pamidronic acid (50 g) is dissolved in hot sodium hydroxide solution (150 ml) of 12.5% p/v (parts/volume) at 90° C. and the mixture was adjusted to pH 7.5˜8.5. By filtering the solution, the insoluble material is removed. The filtrate is added to isopropanol (400 ml) which is stirring. After the mixture is cooled to 0° C. filtered and dried in oven at 90° C. white disodium pamidronate (55.8 g. yield 94%) is obtained.

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