Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2-{4-[2-(4-Fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-ethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | {4-[2-(4-Fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-acetonitrile | HCID 18619854 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-{4-[2-(4-Fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-ethylamine | HCID 18619830 | — |
반응 단계
A mixture of {4-[2-(4-fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-acetonitrile (14.8 g), liquid ammonia (8.4 g) and Raney-nickel (4.5 g) in tetrahydrofuran (120 ml) is shaken in an autoclave under hydrogen (130 bar) at +60° C. for 2 hours. The reaction mixture is filtered and evaporated. 2-{4-[2-(4-Fluoro-phenoxy)-ethoxy]-3-methoxy-phenyl}-ethylamine is obtained as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06538016B2 |
| 출처 데이터셋 | uspto-grants-2003_03 |
| ORD ID | ord-d70083d22771496486db7af597fc32f4 |
| 출처 메모 | uspto-grants-2003_03 |