Water → HCID 2794448, 화합물

HRID 1862518노트

반응식

HRID 1862518 반응식
[C:1](OC(C)(C)C)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([O:21][CH3:22])[CH:20]=1)[NH2:17].CS(O)(=O)=O.O>C1(C)C(C)=CC=CC=1>[CH3:22][O:21][C:19]1[CH:20]=[C:14]([O:13][CH3:12])[CH:15]=[C:16]2[C:18]=1[C:3]([CH3:5])=[CH:2][C:1](=[O:6])[NH:17]2

참가 물질

6

반응물 4

HCID 962WaterHCID 6395Methanesulfonic AcidHCID 15538Tert-butyl acetoacetateHCID 663013,5-Dimethoxyaniline

생성물 1

HCID 2794448HCID 2794448, 화합물

시약·촉매·용매 1

HCID 7237O-Xylene용매

반응 조건

온도
125 °C

실험 절차

tert-Butyl acetoacetate (1.58 g) was heated to 120° C. and 3,5-dimethoxyaniline (1.53 g) dissolved in xylene (4 ml) was added. The mixture was heated at 120-130° C. for 20 minutes and then cooled to room temperature. Methanesulfonic acid (2 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. Water (40 ml) was added and the precipitate filtered and dried. Yield 1.31 g (60%).

후처리

  1. additionwas added
  2. temperaturecooled to room temperature
  3. filtrationthe precipitate filtered
  4. customdried

출처 및 근거

ORD 기록
ord-97eac927c7904f0ea7e0b93ccfd9f07e
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06538022B1

반응 노트

불러오는 중…