Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-(t-Butyldimethylsilyloxymethyl)phenyl 2-(acetyloxy)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Acetoxybenzoyl chloride | HCID 79668 | — |
| 반응물 | 3-((((1,1-Dimethylethyl)dimethylsilyl)oxy)methyl)phenol | HCID 14940556 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-(t-Butyldimethylsilyloxymethyl)phenyl 2-(acetyloxy)benzoate | HCID 12071054 | 100% |
반응 단계
To a solution of Compound 3 in Et2O (120 ml) were added acetylsalicyloyl chloride (Compound 4) (5.9 g, 0.028 mol) and triethylamine (Et3N) (6.6 ml, 0.047 mol) in sequence at RT. The reaction mixture was stirred at RT under argon for 3 days. The reaction mixture was diluted with EtOAc (100 ml) and washed with aqueous saturated NaHCO3 (3×100 ml), brine (1×100 ml), and dried over anhydrous Na2SO4. The crude product obtained upon concentration was purified by column chromatography (elution solvent: 5% EtOAc in hexanes) to produce 9.4 g of Compound 5 in 100% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06538033B2 |
| 출처 데이터셋 | uspto-grants-2003_03 |
| ORD ID | ord-e698fe58e16d4fa2a1f2009aa22ff3b1 |
| 출처 메모 | uspto-grants-2003_03 |