HCID 9881809, 화합물 → Methyl 3-(3-cyanophenyl)-5-(formyl)benzoate

HRID 1862571노트

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HRID 1862571 반응식
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([CH:16]=[C:17]([CH2:19][OH:20])[CH:18]=2)[C:12]([O:14][CH3:15])=[O:13])[CH:6]=[CH:7][CH:8]=1)#[N:2]>ClCCl.[O-2].[O-2].[Mn+4]>[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([CH:16]=[C:17]([CH:19]=[O:20])[CH:18]=2)[C:12]([O:14][CH3:15])=[O:13])[CH:6]=[CH:7][CH:8]=1)#[N:2]

참가 물질

4

반응물 1

HCID 9881809HCID 9881809, 화합물

생성물 1

HCID 9795280Methyl 3-(3-cyanophenyl)-5-(formyl)benzoate수율 85.2%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

In 200 ml of dichloromethane, was dissolved 9.05 g of the compound obtained in Example 1, 2 or 3. To the resulting solution, was added 20.6 g of manganese dioxide. The obtained mixture was stirred at room temperature for 40 hours. The reaction solution was filtered through Celite, and the Celite was further washed with dichloromethane. Each filtrate was combined into one portion, and the solvent was removed under reduced pressure to afford 7.65 g (85%) of the title compound as a white crystal.

후처리

  1. filtrationThe reaction solution was filtered through Celite
  2. washthe Celite was further washed with dichloromethane
  3. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-5445b772c26a4715a503bcd52140ff90
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06538137B1

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