Triethylsilane → Ethyl 2-[2-bromo-4-(2-bromoethyl)phenoxy]acetate

HRID 1862601노트

반응식

HRID 1862601 반응식
[Br:1][C:2]1[CH:14]=[C:13]([C:15](=O)[CH2:16][Br:17])[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].C([SiH](CC)CC)C>FC(F)(F)C(O)=O>[Br:1][C:2]1[CH:14]=[C:13]([CH2:15][CH2:16][Br:17])[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

4

반응물 2

HCID 12052TriethylsilaneHCID 18620130Ethyl 2-[2-bromo-4-(2-bromoacetyl)phenoxy]acetate

생성물 1

HCID 15895328Ethyl 2-[2-bromo-4-(2-bromoethyl)phenoxy]acetate수율 90.1%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

반응 조건

온도
50 °C

실험 절차

To a solution of ethyl 2-[2-bromo-4-(2-bromoacetyl)phenoxy]acetate (2.12 g) in trifluoroacetic acid (4.29 ml) was added triethylsilane (2.67 ml), and the mixture was stirred for 1 hour at 50° C. After concentration of the reaction mixture under reduced pressure, purification of the residue by medium pressure liquid column chromatography on silica gel (eluent: hexane/ethyl acetate=5/1) gave ethyl 2-[2-bromo-4-(2-bromoethyl)phenoxy]acetate (1.84 g).

후처리

  1. customAfter concentration of the reaction mixture under reduced pressure, purification of the residue by medium pressure liquid column chromatography on silica gel (eluent: hexane/ethyl acetate=5/1)

출처 및 근거

ORD 기록
ord-b4083cb0c299407db04e764c7c9fb9a7
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06538152B1

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