Ethyl bromoacetate → Ethyl 2-(5-chloro-2-methoxyphenoxy)acetate

HRID 1862610노트

반응식

HRID 1862610 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([CH:7]=1)[O:8][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 588774Phenol, 5-chloro-2-methoxy-

생성물 1

HCID 18620157Ethyl 2-(5-chloro-2-methoxyphenoxy)acetate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 5-chloro-2-methoxyphenol (488 mg) in acetone (15 ml) were added cesium carbonate (1.20 g) and ethyl bromoacetate (375 μl), and the mixture was stirred for 1 hour at room temperature. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. Purification of the residue by flash column chromatography on silica gel (eluent: hexane/ethyl acetate=6/1) gave ethyl 2-(5-chloro-2-methoxyphenoxy)acetate (572 mg).

후처리

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customPurification of the residue by flash column chromatography on silica gel (eluent: hexane/ethyl acetate=6/1)

출처 및 근거

ORD 기록
ord-6bb59a5168c14f8da619c4cdbac83b5c
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06538152B1

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