Potassium Carbonate → 7-[(4-Nitrophenyl)methoxy]-3-phenylchromen-4-one

HRID 1862864

반응식

HRID 1862864 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:18])[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:8][O:9]2)=[CH:4][CH:3]=1.[N+:19]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26]I)=[CH:24][CH:23]=1)([O-:21])=[O:20].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[N+:19]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26][O:1][C:2]2[CH:11]=[C:10]3[C:5]([C:6](=[O:18])[C:7]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)=[CH:8][O:9]3)=[CH:4][CH:3]=2)=[CH:24][CH:23]=1)([O-:21])=[O:20]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 76598alpha-Iodo-p-nitrotolueneHCID 53768917-Hydroxyisoflavone

생성물 1

HCID 15228077-[(4-Nitrophenyl)methoxy]-3-phenylchromen-4-one

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

10.5 g of 7-hydroxy-isoflavone in 200 ml of anhydrous acetone are boiled for 2 hours with 11.8 g of p-nitrobenzyl iodide in the presence of 5.7 g of anhydrous potassium carbonate under reflux condenser. On distilling off about half of the volume of acetone, the residue is poured onto 1000 ml of water. The precipitating crude product is subjected to suction and recrystallized from glacial acetic acid, affording light yellow plates of 7-p-nitrobenzyloxy-isoflavone, m.p. 225°-226° C.

후처리

  1. temperatureunder reflux condenser
  2. distillationOn distilling off about half of the volume of acetone
  3. additionthe residue is poured onto 1000 ml of water
  4. customrecrystallized from glacial acetic acid

출처 및 근거

ORD 기록
ord-a61f1c4e9df04bcb8c154ed451741622
출처 데이터셋
uspto-grants-1979_09
특허 번호
US04166862

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