Carbon Dioxide → 2,2,2-Trichloroethyl 3-bromo-2-oxopropanoate

HRID 1862869노트

반응식

HRID 1862869 반응식
[C:1]([O:6][CH2:7][C:8]([Cl:11])([Cl:10])[Cl:9])(=[O:5])[C:2]([CH3:4])=[O:3].[Br:12]Br.C(=O)=O>O>[Br:12][CH2:4][C:2](=[O:3])[C:1]([O:6][CH2:7][C:8]([Cl:9])([Cl:10])[Cl:11])=[O:5]

참가 물질

5

반응물 3

HCID 280Carbon DioxideHCID 24408BromineHCID 129644372,2,2-Trichloroethyl 2-oxopropanoate

생성물 1

HCID 143497182,2,2-Trichloroethyl 3-bromo-2-oxopropanoate수율 35.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Trichloroethyl pyruvate (3.7 g, 17 mmole) is heated to 65° and 1.1 ml (17 mmole) of bromine is added dropwise over 1 hour. A stream of carbon dioxide is passed through the reaction mixture during the addition to remove the HBr formed in the reaction. The mixture is cooled to room temperature, diluted with water and extracted with ethyl acetate. The extract is dried over MgSO4, evaporated and distilled in vacuum to give 1.8 g of trichloroethyl bromopyruvate, bp 74°-77° (0.01 mm).

후처리

  1. customto remove the HBr
  2. customformed in the reaction
  3. extractionextracted with ethyl acetate
  4. dry with materialThe extract is dried over MgSO4
  5. customevaporated
  6. distillationdistilled in vacuum

출처 및 근거

ORD 기록
ord-936400cb750543c7b72239f4cd3ddc47
출처 데이터셋
uspto-grants-1979_09
특허 번호
US04166816

반응 노트

불러오는 중…