Potassium Iodide → Methyl (m-[m-phenoxyphenoxy]phenoxy)-alpha-[p-(p-chlorophenoxy)phenyl]acetate

HRID 1863300노트

반응식

HRID 1863300 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][CH:21]=1)[O:11][C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[CH:16][CH:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+].[I-].[K+].Br[CH:28]([C:33]1[CH:38]=[CH:37][C:36]([O:39][C:40]2[CH:45]=[CH:44][C:43]([Cl:46])=[CH:42][CH:41]=2)=[CH:35][CH:34]=1)[C:29]([O:31][CH3:32])=[O:30]>CO.C1C=CC=CC=1.O>[O:1]([C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][CH:21]=1)[O:11][C:12]1[CH:13]=[C:14]([CH:15]=[CH:16][CH:17]=1)[O:18][CH:28]([C:33]1[CH:38]=[CH:37][C:36]([O:39][C:40]2[CH:41]=[CH:42][C:43]([Cl:46])=[CH:44][CH:45]=2)=[CH:35][CH:34]=1)[C:29]([O:31][CH3:32])=[O:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

8

반응물 4

HCID 4875Potassium IodideHCID 84251Phenol, 3-(3-phenoxyphenoxy)-HCID 10942334Sodium MethoxideHCID 20392594Methyl alpha-Bromo-alpha-[p-(p-chlorophenoxy)phenyl]acetate

생성물 1

HCID 86736645Methyl (m-[m-phenoxyphenoxy]phenoxy)-alpha-[p-(p-chlorophenoxy)phenyl]acetate

시약·촉매·용매 3

HCID 241Benzene용매HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of 6.96 g of m-(m-phenoxyphenoxy)phenol, 1.19 g of sodium methoxide and 50 mg of potassium iodide in 40 ml of methanol is added 7.11 g of methyl α-bromo-α-[p-(p-chlorophenoxy)phenyl]acetate in 10 ml of benzene. The mixture is refluxed for 20 hours, poured into ice and water and extracted with chloroform. The chloroform extracts are washed with 10% potassium carbonate and with water. The extract is dried over magnesium sulfate and concentrated under vacuum to give an oil. Filtration once through silica gel (chloroform solvent) and again through silica gel with benzene as solvent gives the product as an oil.

후처리

  1. temperatureThe mixture is refluxed for 20 hours
  2. extractionextracted with chloroform
  3. washThe chloroform extracts are washed with 10% potassium carbonate and with water
  4. dry with materialThe extract is dried over magnesium sulfate
  5. concentrationconcentrated under vacuum
  6. customto give an oil
  7. filtrationFiltration once through silica gel (chloroform solvent)

출처 및 근거

ORD 기록
ord-bda675eb7dbd4415a813c129aea4875b
출처 데이터셋
uspto-grants-1979_09
특허 번호
US04168385

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