[5-Methyl-2-(3-methylphenyl)-1H-imidazol-4-yl]methanol → 4-Methyl-2-(3-methylphenyl)-1H-imidazole-5-carboxaldehyde

HRID 1863420노트

반응식

HRID 1863420 반응식
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[C:9]([CH3:13])[CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH2:14][OH:15]>[O-2].[O-2].[Mn+4].C(Cl)Cl>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[C:9]([CH3:13])[CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH:14]=[O:15]

참가 물질

4

반응물 1

HCID 20291433[5-Methyl-2-(3-methylphenyl)-1H-imidazol-4-yl]methanol

생성물 1

HCID 224119984-Methyl-2-(3-methylphenyl)-1H-imidazole-5-carboxaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of 5-methyl-2-m-tolyl-4-imidazolemethanol (13.0 gm., 0.064 mole), activated manganese dioxide (65 gm.) and methylene chloride (200 ml.) is stirred at room temperature for 20 hours. The reaction mixture is then filtered, the solvent removed in vacuo to afford 9.1 gm. (0.045 mole) of peach-colored solid.

후처리

  1. filtrationThe reaction mixture is then filtered
  2. customthe solvent removed in vacuo
  3. customto afford 9.1 gm

출처 및 근거

ORD 기록
ord-b1a6e1542c0f4e1a8aba201cd4ab84df
출처 데이터셋
uspto-grants-1979_09
특허 번호
US04168964

반응 노트

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