Thionyl Chloride → 6,7-Dimethoxy-2-naphthoyl chloride

HRID 1863475노트

반응식

HRID 1863475 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[C:8]([C:15]([OH:17])=O)[CH:7]=[CH:6]2.S(Cl)([Cl:20])=O>CN(C)C=O.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[C:8]([C:15]([Cl:20])=[O:17])[CH:7]=[CH:6]2

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 2830286,7-Dimethoxy-2-naphthoic acid

생성물 1

HCID 218249396,7-Dimethoxy-2-naphthoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 241Benzene용매

실험 절차

To a solution containing 15.0 g. of 6,7-dimethoxy-2-naphthoic acid and one drop of dimethylformamide in 200 ml. of benzene was added 25 ml. of thionyl chloride. After heating one hour under reflux the mixture was evaporated to dryness in vacuo. Additional benzene was added and evaporation repeated to give 6,7-dimethoxy-2-naphthoyl chloride which was used directly in the preparation of 6,7-dimethoxy-2-naphthamide as described hereinabove in Example 113.

후처리

  1. additionTo a solution containing 15.0 g
  2. temperatureAfter heating one hour
  3. temperatureunder reflux the mixture
  4. customwas evaporated to dryness in vacuo
  5. additionAdditional benzene was added
  6. customevaporation

출처 및 근거

ORD 기록
ord-4501dfb1c86a418b9cade2b8f6690a3d
출처 데이터셋
uspto-grants-1979_09
특허 번호
US04169108

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