Tetrahydrofuran → HCID 66832323, 화합물

HRID 1863887노트

반응식

HRID 1863887 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([P:8](Cl)(Cl)=[O:9])=[CH:4][CH:3]=1.[CH:12]([Mg]Br)=[CH2:13].[Cl-].[NH4+].[CH2:18]1COC[CH2:19]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([P:8](=[O:9])([CH:12]=[CH2:13])[CH:18]=[CH2:19])=[CH:4][CH:3]=1

참가 물질

5

반응물 4

HCID 8028Tetrahydrofuran2회HCID 25517Ammonium ChlorideHCID 12670632(4-Fluorophenyl)phosphonic dichlorideHCID 178418507HCID 178418507, 화합물

생성물 1

HCID 66832323HCID 66832323, 화합물수율 83%

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온도
-70 °C

실험 절차

4-Fluorophenyl-phosphonic dichloride (6.86 g, 32.2 mmol) was dissolved in dry THF (50 mL), placed under a nitrogen atmosphere, and chilled to −70° C. To this stirred solution was added dropwise a solution of vinyl magnesium bromide in THF (80.5 mL, 1 M). The resulting solution was stirred for 90 minutes at −70° C. An aqueous solution of ammonium chloride (500 mL, 2 M) was chilled to 0° C. and stirred rapidly while the cold reaction mixture was added. The product was extracted into dichloromethane and washed with saturated aqueous sodium bicarbonate followed by water. The organic phase was dried with sodium sulfate, filtered, and concentrated by rotary evaporation to yield 5.214 g of 4-fluoro-phenyl-divinyl-phosphine oxide (26.6 mmol, 83%) as a white solid. 1H NMR (400 MHz, CDCl3) 7.80-7.71 (m, 2H); 7.25-7.18 (m 2H); 6.56-6.22 (m, 6H); ESMS (m/z): (M+1)+ found, 197.

후처리

  1. stirringstirred rapidly while the cold reaction mixture
  2. additionwas added
  3. extractionThe product was extracted into dichloromethane
  4. washwashed with saturated aqueous sodium bicarbonate
  5. dry with materialThe organic phase was dried with sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated by rotary evaporation

출처 및 근거

ORD 기록
ord-917456b9bf384d3691e9f398c783a47e
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625880B2

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