4-Chloro-2-trifluoromethylpyrazolo[1.5-a]pyrazine → HCID 131727793, 화합물

HRID 1863968노트

반응식

HRID 1863968 반응식
[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:9][C:10]([NH:12][NH2:13])=O)([CH3:4])([CH3:3])[CH3:2].Cl[C:26]1[C:27]2[N:28]([N:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:34]=2)[CH:29]=[CH:30][N:31]=1>>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:9][C:10]1[N:31]2[C:26]([C:27]3[N:28]([N:32]=[C:33]([C:35]([F:38])([F:36])[F:37])[CH:34]=3)[CH:29]=[CH:30]2)=[N:13][N:12]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 579737724-Chloro-2-trifluoromethylpyrazolo[1.5-a]pyrazine2회HCID 57973796HCID 57973796, 화합물2회

생성물 1

HCID 131727793HCID 131727793, 화합물

실험 절차

A mixture of 7.7 mg (0.22 mmol) of tert-butyl[(1R)-3-hydrazino-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate (Intermediate 4), 4.9 mg (0.22 mmol) of 4-chloro-2-(trifluoromethyl)pyrazolo[1,5-a]pyrazine (Intermediate 39), and 0.5 mL of xylenes was stirred at reflux for 19 h. The cooled solution was concentrated to yield the title compound, sufficiently pure for use in the next step. LC-MS 515 (M+1).

후처리

  1. temperatureat reflux for 19 h
  2. concentrationThe cooled solution was concentrated

출처 및 근거

ORD 기록
ord-d5798a9a36ef485a85a8301247a78eaf
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625888B2

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