p-Bromobenzyl chloride → 1-Bromo-4-{[(2S)-3-methoxy-2-methylpropoxy]methyl}benzene

HRID 1863974노트

반응식

HRID 1863974 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][CH:3]=1.[CH3:10][O:11][CH2:12][C@H:13]([CH3:16])[CH2:14][OH:15]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:15][CH2:14][C@@H:13]([CH3:16])[CH2:12][O:11][CH3:10])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 68528p-Bromobenzyl chlorideHCID 56924404(2R)-3-Methoxy-2-methylpropan-1-ol

생성물 1

HCID 454896741-Bromo-4-{[(2S)-3-methoxy-2-methylpropoxy]methyl}benzene

실험 절차

According to general method E, 1-bromo-4-chloromethyl-benzene [589-17-3] and (R)-3-methoxy-2-methyl-propan-1-ol are used to afford the title compound as a yellow oil. Rf=0.44 (EtOAc-heptane 1:6); Rt=5.29 (gradient I).

출처 및 근거

ORD 기록
ord-8cf95cef1454405c80effb01aa4b2b4e
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625893B2

반응 노트

불러오는 중…