Glycolic Acid → HCID 69055632, 화합물

HRID 1864254노트

반응식

[C:1]([OH:5])(=O)[CH2:2][OH:3].[Cl:6][C:7]1[CH:12]=[C:11]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][C:22]=3[O:24][CH2:25][C@H:26]([NH:28][CH3:29])[CH3:27])[N:17]=[CH:16][N:15]=2)[CH:10]=[CH:9][C:8]=1[OH:30]>>[Cl:6][C:7]1[CH:12]=[C:11]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][C:22]=3[O:24][CH2:25][C@H:26]([N:28]([CH3:29])[C:1](=[O:5])[CH2:2][OH:3])[CH3:27])[N:17]=[CH:16][N:15]=2)[CH:10]=[CH:9][C:8]=1[OH:30]

참가 물질

반응물 2

HCID 757Glycolic Acid

HCID 69057167HCID 69057167, 화합물

생성물 1

HCID 69055632HCID 69055632, 화합물수율 100%

실험 절차

The procedure described in Example 3 (preparation of starting materials) was repeated using glycolic acid and 2-chloro-4-[(5-{[(2R)-2-(methylamino)propyl]oxy}quinazolin-4-yl)amino]phenol to give N-[(1R)-2-({4-[(3-chloro-4-hydroxyphenyl)amino]quinazolin-5-yl}oxy)-1-methylethyl]-2-hydroxy-N-methylacetamide in 100% yield; Mass spectrum MH+ 416.9.

후처리

customThe procedure described in Example 3 (preparation of starting materials)

출처 및 근거

ORD 기록: ord-4c8c8ac06e98461ca7932f2501f5d5db
출처 데이터셋: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07625908B2

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