1-(4-Methylpyridin-2-yl)piperazine → (RS)-1-Benzenesulfonyl-3-cyclohexyl-4-[4-(4-methyl-pyridin-2-yl)-piperazine-1-carbonyl]-imidazolidin-2-one
반응식
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15](O)=[O:16])[N:12]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:25][C:26]1[CH:31]=[CH:30][N:29]=[C:28]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:27]=1>>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]([N:35]3[CH2:36][CH2:37][N:32]([C:28]4[CH:27]=[C:26]([CH3:25])[CH:31]=[CH:30][N:29]=4)[CH2:33][CH2:34]3)=[O:16])[N:12]([CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[C:11]2=[O:24])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
3
실험 절차
In analogy to example 1, (RS)-1-benzenesulfonyl-3-cyclohexyl-2-oxo-imidazolidine-4-carboxylic acid (example 39, step 4) was coupled with 1-(4-methyl-pyridin-2-yl)piperazine to give the title compound as a colorless solid. MS: 512.3 ([M+H]+)
출처 및 근거
- ORD 기록
- ord-83a6a385a09f4cb2b1096bd42469e080
- 출처 데이터셋
- uspto-grants-2009_12